Selenium plasma levels in children with Helicobacter pylori-associated diseases of the upper gastrointestinal tract

Despite the success of treatment infected individuals, Helicobacter pylori infection remains most common human bacterial pathogen, infecting half world’s population. In a large part people, H. causes gastroduodenal diseases, in particular, chronic antral gastritis and ulcer disease. The possible role selenium course inflammatory pylori-associated pathology upper gastrointestinal tract children has not yet been fully investigated understood. aim is to determine plasma levels with diseases tract. Materials methods. study included 135 school-age tract, who made up main group (55 (CG), 57 gastroduodenitis (CGD), 23 duodenal (DU), 20 practically healthy age-matched were comparison group. Quantitative measurements performed using inductively coupled mass spectrometry (MS-ICP) on an Optima 2000 DV spectrometer (Perkin Elmer, USA). Results. lowest level was registered pylori-negative DU (67.81 ± 2.67 μg/l), while DU, its higher – 73.56 2.34 μg/l (p < 0.05), however, it did reach A similar direction changes concentration observed CGD: detected pylori-positive CGD compared (75.61 2.48 70.99 2.31 μg/l, respectively, p 0.05). Conclusions. Significantly lower destructive-inflammatory found, which could be explained by acute phase inflammation mucous membrane stomach duodenum resulting decrease absorption. children, significantly indicating pathogenesis further progression diseases.